Scientists report inhibition of cellular aging
Originally shared by Ward Plunet
Scientists report inhibition of cellular aging
Aging is the deterioration of a cell's ability to divide and grow as it gets older. This causes degradation of the body and age-related diseases. Prevention of aging is an instinctive desire of humans; thus, it is a task and challenge of biologists to identify substances that control aging and analyze aging mechanisms. DGIST's research team have been conducting research to reverse the aging process by shifting the existing academia's 'irreversibility of aging' paradigm that suggests aging cannot be reversed. To reverse the aging process, the research team searched for factors that could control aging and sought substances that could restore cell division capacity. As a result, it was confirmed that KU-60019, an inhibitor of the ATM protein, which is a phosphorylation enzyme, restores the functions of aging cells through activation of lysosomal functions and induction of cell proliferation. The degradation of lysosomes, which are intracellular organelles responsible for autophagy and decomposition of biopolymers such as proteins and lipids in the cell, leads to cell senescence by accumulating biomolecules that must be removed in cells and causes instability of the metabolism such as removal of dysfunctional mitochondria.
https://phys.org/news/2017-04-scientists-inhibition-cellular-aging.html#jCp
Scientists report inhibition of cellular aging
Aging is the deterioration of a cell's ability to divide and grow as it gets older. This causes degradation of the body and age-related diseases. Prevention of aging is an instinctive desire of humans; thus, it is a task and challenge of biologists to identify substances that control aging and analyze aging mechanisms. DGIST's research team have been conducting research to reverse the aging process by shifting the existing academia's 'irreversibility of aging' paradigm that suggests aging cannot be reversed. To reverse the aging process, the research team searched for factors that could control aging and sought substances that could restore cell division capacity. As a result, it was confirmed that KU-60019, an inhibitor of the ATM protein, which is a phosphorylation enzyme, restores the functions of aging cells through activation of lysosomal functions and induction of cell proliferation. The degradation of lysosomes, which are intracellular organelles responsible for autophagy and decomposition of biopolymers such as proteins and lipids in the cell, leads to cell senescence by accumulating biomolecules that must be removed in cells and causes instability of the metabolism such as removal of dysfunctional mitochondria.
https://phys.org/news/2017-04-scientists-inhibition-cellular-aging.html#jCp
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