#health #neuroscience

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#health   #neuroscience  

Originally shared by Ward Plunet

Vicious Cycle: Obesity Sustained by Changes in Brain Biochemistry

...researchers show that in the brain cells of rats, obesity impedes the production of a hormone that curbs appetite and inspires calorie burning. The root cause appears to be a breakdown in the protein-processing mechanism of the cells. In the lab, the researchers showed they could fix the breakdown with drugs.

#sciencesunday  
#obesity  
#health  
#brain  

Journal Reference:
I. Cakir, N. E. Cyr, M. Perello, B. Patedakis Litvinov, A. Romero, R. C. Stuart, E. A. Nillni. Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing. Journal of Biological Chemistry, 2013; DOI: 10.1074/jbc.M113.475343
http://www.sciencedaily.com/releases/2013/05/130516105511.htm

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