Scientists in the United States have developed a simple and robust approach for directly reprogramming mature skin...
Originally shared by Manuela Casasoli
Scientists in the United States have developed a simple and robust approach for directly reprogramming mature skin cells into immature muscle cells.
[...]
In conclusion, our study reports on a simple and robust approach to generate expandable, non-transformed myogenic cell populations with characteristics of muscle stem cells directly from fibroblasts and muscle tissue. Our results also raise the intriguing possibility that any other stem/progenitor populations of interest could be derived using similar principles, i.e., overexpression of differentiation-associated transcription factors and pharmacological suppression of pathways that resist reprogramming.
Bar-Nur et al. (2018) Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors:
1)https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(18)30177-2
2)https://www.cell.com/stem-cell-reports/pdf/S2213-6711(18)30177-2.pdf
https://eurekalert.org/pub_releases/2018-05/cp-cra050218.php
Scientists in the United States have developed a simple and robust approach for directly reprogramming mature skin cells into immature muscle cells.
[...]
In conclusion, our study reports on a simple and robust approach to generate expandable, non-transformed myogenic cell populations with characteristics of muscle stem cells directly from fibroblasts and muscle tissue. Our results also raise the intriguing possibility that any other stem/progenitor populations of interest could be derived using similar principles, i.e., overexpression of differentiation-associated transcription factors and pharmacological suppression of pathways that resist reprogramming.
Bar-Nur et al. (2018) Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors:
1)https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(18)30177-2
2)https://www.cell.com/stem-cell-reports/pdf/S2213-6711(18)30177-2.pdf
https://eurekalert.org/pub_releases/2018-05/cp-cra050218.php
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